After being used for more than a decade the use of hydroxyethyl starch (HES) 130/0.38–0.45 in clinical practice was discouraged because of serious adverse events including bleeding, acute kidney injury… Click to show full abstract
After being used for more than a decade the use of hydroxyethyl starch (HES) 130/0.38–0.45 in clinical practice was discouraged because of serious adverse events including bleeding, acute kidney injury and death. But could these adverse effects have been discovered sooner? By comparing the summary effect estimates of the adverse effects of HES 130/0.38–0.45 in different study designs we aimed to disclose any signal of this.
               
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