Adult intensive care unit (ICU) patients receive many interventions, but few are supported by high‐certainty evidence. Randomised clinical trials (RCTs) are essential for trustworthy comparisons of intervention effects, but conventional… Click to show full abstract
Adult intensive care unit (ICU) patients receive many interventions, but few are supported by high‐certainty evidence. Randomised clinical trials (RCTs) are essential for trustworthy comparisons of intervention effects, but conventional RCTs are costly, cumbersome, inflexible, and often turn out inconclusive. Adaptive platform trials may mitigate these issues and have higher probabilities of obtaining conclusive results faster and at lower costs per participant.
               
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