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Ventral striatum regulates behavioral response to ethanol and MDMA combination

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Our previous studies consistently showed that MDMA‐induced locomotor hyperactivity is dramatically increased by coadministration of ethanol (EtOH) in rats, indicating possible potentiation of MDMA abuse liability. Thus, we aimed to… Click to show full abstract

Our previous studies consistently showed that MDMA‐induced locomotor hyperactivity is dramatically increased by coadministration of ethanol (EtOH) in rats, indicating possible potentiation of MDMA abuse liability. Thus, we aimed to identify the brain region(s) and neuropharmacological substrates involved in the pharmacodynamics of this potentiation.

Keywords: striatum regulates; ventral striatum; regulates behavioral; behavioral response; mdma; ethanol

Journal Title: Addiction Biology
Year Published: 2020

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