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Esomeprazole‐induced ashy dermatosis‐like drug eruptions

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Ashy dermatosis is characterised by asymptomatic grey-toblue colour macules of various shapes and sizes. These skin lesions are commonly symmetrically distributed on the trunk. This condition presents from childhood through… Click to show full abstract

Ashy dermatosis is characterised by asymptomatic grey-toblue colour macules of various shapes and sizes. These skin lesions are commonly symmetrically distributed on the trunk. This condition presents from childhood through adult life with no gender predilection. Although the aetiology remains unknown, several associated factors have been reported, including medications. We described a 75-year-old woman with a history of type 2 diabetes mellitus and gastroesophageal reflux disease referred to our dermatology department for an increasing number of asymptomatic cutaneous lesions on her trunk for 1 month. Esomeprazole (40 mg/day) had been prescribed for her gastroesophageal reflux disease about 2 months before the onset of the lesions. On examination, multiple polymorphous grey-to-blue macules and patches were observed on the trunk in a symmetrical distribution (Fig. 1a–c). An incisional biopsy was taken from a macule on her back. Histopathology revealed hyperkeratosis with basal vascular change and superficial perivascular lymphocytic infiltrations. Furthermore, occasional colloid bodies in the epidermis and

Keywords: dermatosis like; dermatology; ashy dermatosis; esomeprazole induced; induced ashy

Journal Title: Australasian Journal of Dermatology
Year Published: 2018

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