LAUSR

atinocytes, into amyloid in the papillary dermis. The second theory hypothesises that degenerated basal keratinocytes pass through damaged lamina densa into the papillary dermis. The presence of antigen-rich degenerated cells in the papillary dermis could represent the source of autoimmune responses. This scenario could justify the relationship among autoimmune disorders with primary localised cutaneous amyloidosis. Other immune disorders linked to primary localised cutaneous amyloidosis have been reported such as Sj€ ogren syndrome, CREST (Calcinosis, Raynaud phenomenon, Oesophageal dysmotility, Sclerodactyly and Telangiectasia) syndrome, ankylosing spondylitis, autoimmune thyroiditis or primary biliary cirrhosis. This report describes the combination of seronegative spondyloarthritis with macular amyloidosis and extends the list of immune disorders combined with primary localised cutaneous amyloidosis, confirming the strict relationship between cutaneous amyloidosis and autoimmune diseases.