sentation on the eyelid. In addition, a multicentre prospective study of 38 children with idiopathic aseptic facial granuloma found 42% to have at least two clinical signs of childhood rosacea,… Click to show full abstract
sentation on the eyelid. In addition, a multicentre prospective study of 38 children with idiopathic aseptic facial granuloma found 42% to have at least two clinical signs of childhood rosacea, such as papulopustules and flushing. None of these signs were found in our patients; however, we noted that two patients had a family history of nodulocystic acne, requiring oral isotretinoin therapy, and one of them has since developed nodulocystic acne in adolescence, also treated with oral isotretinoin. With the knowledge that inflammatory granulomata are seen with some forms of adult acne, that scarring is not a feature of rosacea and that the lesions are localised to the face, we postulate that idiopathic aseptic facial granuloma could also be a childhood form of nodulocystic acne. We suggest that oral isotretinoin can be considered as a safe possible medical therapy for patients with progressive and distressing idiopathic aseptic facial granuloma.
               
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