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fibroblast growth factors (FGF) play an essential role in bone regeneration after fracture through regulating osteoblast proliferation and differentiation. In addition to other FGFs, it is shown that FGF5 and… Click to show full abstract
fibroblast growth factors (FGF) play an essential role in bone regeneration after fracture through regulating osteoblast proliferation and differentiation. In addition to other FGFs, it is shown that FGF5 and FGF7 are associated with the hair growth cycle regulation. Lin et al. have demonstrated that hair growth could be enhanced through induction of anagen phase after topical application and subcutaneous injection of FGF1, FGF2 and FGF10 in mice. This report elaborates on a new possible explanation of the post-fracture hypertrichosis by discussing transient localised acquired hypertrichosis after bone lengthening without the application of skin cover. We suggest that hair growth could be enhanced by the indirect activation of the dermal fibroblast of the affected area under the influence of the different FGFs participating in post-fracture osteosynthesis.
Journal Title: Australasian Journal of Dermatology
Year Published: 2020
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