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Disseminated superficial actinic porokeratosis (DSAP) is a porokeratosis variant that is cosmetically disfiguring and may be associated with squamous cell carcinoma. It is an autosomal dominant condition caused by germline… Click to show full abstract
Disseminated superficial actinic porokeratosis (DSAP) is a porokeratosis variant that is cosmetically disfiguring and may be associated with squamous cell carcinoma. It is an autosomal dominant condition caused by germline mutations in mevalonate pathway genes involved in cholesterol synthesis. Lesions are precipitated by ultraviolet radiation‐induced second‐hit mutations. Modulation of this pathway by topical simvastatin–cholesterol may lead to improvement.
Keywords:
disseminated superficial;
topical simvastatin;
superficial actinic;
cholesterol;
porokeratosis;
actinic porokeratosis
Journal Title: Australasian Journal of Dermatology
Year Published: 2021
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Journal Title: Australasian Journal of Dermatology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!