The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic‐pituitary‐adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the… Click to show full abstract
The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic‐pituitary‐adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the inflammatory and stress response. Although the glucocorticoid receptor (GR) is expressed in all human villous trophoblast tissue, the effect of glucocorticoids on placentation is not well understood.
               
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