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Decidual stromal cell‐derived PGE2 regulates macrophage responses to microbial threat

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Bacterial chorioamnionitis causes adverse pregnancy outcomes, yet host‐microbial interactions are not well characterized within gestational membranes. The decidua, the outermost region of the membranes, is a potential point of entry… Click to show full abstract

Bacterial chorioamnionitis causes adverse pregnancy outcomes, yet host‐microbial interactions are not well characterized within gestational membranes. The decidua, the outermost region of the membranes, is a potential point of entry for bacteria ascending from the vagina to cause chorioamnionitis. We sought to determine whether paracrine communication between decidual stromal cells and macrophages shaped immune responses to microbial sensing.

Keywords: responses microbial; stromal cell; cell derived; derived pge2; pge2 regulates; decidual stromal

Journal Title: American Journal of Reproductive Immunology
Year Published: 2018

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