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Placental infection induces increased levels of pro‐inflammatory cytokines, which have been implicated in the pathogenesis of pre‐term labor. Endotoxin tolerance is a phenomenon in which exposure to a dose of… Click to show full abstract
Placental infection induces increased levels of pro‐inflammatory cytokines, which have been implicated in the pathogenesis of pre‐term labor. Endotoxin tolerance is a phenomenon in which exposure to a dose of endotoxin makes tissue less responsive to subsequent exposures. The objective of our study was to determine whether repeated exposure to endotoxin will induce a tolerant phenotype in normal human second‐trimester placental tissue.
Keywords:
endotoxin;
exposure;
repeated lipopolysaccharide;
lipopolysaccharide exposure;
endotoxin tolerance
Journal Title: American Journal of Reproductive Immunology
Year Published: 2019
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Journal Title: American Journal of Reproductive Immunology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!