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Decreased effector regulatory T cells and increased activated CD4+ T cells in premature ovarian insufficiency

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Premature ovarian insufficiency (POI) is a clinical syndrome defined by the loss of ovarian activity before 40 years old. An autoimmune mechanism is suggested to be involved in the development… Click to show full abstract

Premature ovarian insufficiency (POI) is a clinical syndrome defined by the loss of ovarian activity before 40 years old. An autoimmune mechanism is suggested to be involved in the development of POI. Therefore, we examined the relationship between peripheral blood regulatory T (Treg) cells and autoantibodies in POI.

Keywords: decreased effector; effector regulatory; regulatory cells; ovarian insufficiency; premature ovarian

Journal Title: American Journal of Reproductive Immunology
Year Published: 2019

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