LAUSR

Drug allergy is associated with adverse short‐term perinatal outcomes such as caesarian delivery and preterm delivery. The aim of the present study was to determine whether being born to a mother with known drug allergy increases the risk for long‐term dermatological morbidity of the offspring. A population‐based cohort study, comparing long‐term dermatological morbidity of offspring to mothers with and without known drug allergy, was conducted. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD‐9 codes associated with hospitalization of the offspring. A Kaplan‐Meier survival curve was used to compare cumulative incidence of long‐term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders. During the study period, 243,682 deliveries met the inclusion criteria, of them 4% (n = 9756) were of mothers with known drug allergy. Offspring born to mothers with known drug allergy had higher rates of long‐term dermatological morbidity Likewise, the cumulative incidence of long‐term dermatological morbidity was higher as compared with those without known drug allergy (Kaplan‐Meier log‐rank P = .021). Using a Cox proportional hazards model, controlling for confounders, being born to a mother with known drug allergy was found to be an independent risk factor for long‐term dermatological morbidity of the offspring (adjusted HR 1.2, 95% CI 1.03‐1.33, P = .016). Being born to a mother with known drug allergy is independently associated with higher risk for long‐term dermatological morbidity of the offspring.