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Triaging abnormal cervical cancer screening tests using p16INK4a detection by ELISA on fresh cervical samples

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Cervical cancer screening strategies in the United States include cotesting (human papillomavirus (HPV) with cytology), primary HPV with genotyping and reflex cytology, and cytology alone. An ongoing challenge is the… Click to show full abstract

Cervical cancer screening strategies in the United States include cotesting (human papillomavirus (HPV) with cytology), primary HPV with genotyping and reflex cytology, and cytology alone. An ongoing challenge is the appropriate triage of patients to colposcopy to those at highest risk. We investigated whether incorporation of p16INK4a immunodetection by enzyme‐linked immunosorbent assay (ELISA) on fresh cervical samples obtained at the time of screening could improve appropriate referral to colposcopy.

Keywords: cervical samples; cancer screening; cervical cancer; elisa fresh; cytology; fresh cervical

Journal Title: American Journal of Reproductive Immunology
Year Published: 2021

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