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Treatment of high fat diet‐induced obese pregnant mice with IL‐6 receptor antibody does not ameliorate placental function and fetal growth restriction

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: Pregnancy complications and adverse birth outcomes are in part fueled by the rise in obesity and its associated co‐morbidities in western societies. Fetal healthy development and placental function are… Click to show full abstract

: Pregnancy complications and adverse birth outcomes are in part fueled by the rise in obesity and its associated co‐morbidities in western societies. Fetal healthy development and placental function are disturbed by an obese, inflammatory environment associated with cytokines, such as interleukin‐6, causing inadequate supply of nutrients to the fetus and perinatal programming with severe health consequences.

Keywords: treatment high; function; placental function; high fat; diet induced; fat diet

Journal Title: American Journal of Reproductive Immunology
Year Published: 2022

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