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Roles of natural resistance‐associated macrophage protein‐1 in modulating bacterial distribution and immune responses during Salmonella enterica serovar Typhimurium infection in murine pregnancy

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Salmonella enterica serovar Typhimurium (S.Tm) infection in Nramp1+/+ mice during pregnancy can lead to profound bacterial growth in the feto‐placental unit and adverse pregnancy outcomes, including fetal loss, maternal illness… Click to show full abstract

Salmonella enterica serovar Typhimurium (S.Tm) infection in Nramp1+/+ mice during pregnancy can lead to profound bacterial growth in the feto‐placental unit and adverse pregnancy outcomes, including fetal loss, maternal illness and death. The kinetics and mechanisms by which S.Tm gains entry within individual feto‐placental unit, and disseminates through tissues leading to placental resorption and fetal demise remain unclear.

Keywords: typhimurium infection; serovar typhimurium; pregnancy; enterica serovar; salmonella enterica

Journal Title: American Journal of Reproductive Immunology
Year Published: 2022

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