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NKG2D‐mediated cytotoxicity improves after primary surgery for high‐grade serous ovarian cancer

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Tumors compromise the patients’ immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity. Primary surgery's effect on tumor… Click to show full abstract

Tumors compromise the patients’ immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity. Primary surgery's effect on tumor exosomes and NKG2D cytotoxicity in HGSC patients has not been studied before. The overall objective of this study was to explore the effect of surgery on the exosome‐induced impairment of NKG2D cytotoxicity in HGSC.

Keywords: cytotoxicity; mediated cytotoxicity; nkg2d mediated; primary surgery; nkg2d cytotoxicity

Journal Title: American Journal of Reproductive Immunology
Year Published: 2022

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