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The overexpression of neurokinin B–neurokinin 3 receptor system exerts direct effects on the ovary under PCOS‐like conditions to interfere with mitochondrial function

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The increased hypothalamic neurokinin B (NKB) level may contribute to the hyperactive LH pulse secretion in Polycystic ovary syndrome (PCOS). However, the expression and role of the neurokinin B‐neurokinin 3… Click to show full abstract

The increased hypothalamic neurokinin B (NKB) level may contribute to the hyperactive LH pulse secretion in Polycystic ovary syndrome (PCOS). However, the expression and role of the neurokinin B‐neurokinin 3 receptor (NKB‐NK3R) system in the local ovarian tissue of PCOS have not been clarified. We constructed in vivo and in vitro models to elucidate the mechanism of the NKB‐NK3R pathway in reproductive endocrine disorders of PCOS.

Keywords: system; neurokinin receptor; overexpression neurokinin; neurokinin; neurokinin neurokinin

Journal Title: American Journal of Reproductive Immunology
Year Published: 2022

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