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Increased fetal microchimerism in immune and stem cell subsets in preeclampsia

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Preeclampsia (PE) is associated with an increased risk of maternal cardiovascular disease (CVD), however, it is unclear whether this is due to shared underlying physiology or changes which occur during… Click to show full abstract

Preeclampsia (PE) is associated with an increased risk of maternal cardiovascular disease (CVD), however, it is unclear whether this is due to shared underlying physiology or changes which occur during the disease process. Fetal microchimerism (FMc) within the maternal circulation can durably persist decades after pregnancy, is known to occur at greater frequency in PE, and can potentially affect local and systemic immune programming, thus changes in cellular FMc may provide a mechanism for longā€term health outcomes associated with PE.

Keywords: microchimerism; stem cell; fetal microchimerism; increased fetal; microchimerism immune; immune stem

Journal Title: American Journal of Reproductive Immunology
Year Published: 2022

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