Gonadotropin‐releasing hormone (GnRH), primarily known for its hypothalamic role in regulating gonadotropin secretion, is also expressed in extra‐hypothalamic tissues, including trophoblasts at implantation sites. We investigated the association between trophoblasts… Click to show full abstract
Gonadotropin‐releasing hormone (GnRH), primarily known for its hypothalamic role in regulating gonadotropin secretion, is also expressed in extra‐hypothalamic tissues, including trophoblasts at implantation sites. We investigated the association between trophoblasts and mast cells, demonstrating their role in producing leukemia inhibitory factor (LIF) and matrix metalloproteinase‐9 (MMP‐9). Therefore, we hypothesized an additional interaction between trophoblasts and mast cells mediated by GnRH.
Journal Title: American Journal of Reproductive Immunology
Year Published: 2025
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