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The role of non‐invasive prenatal testing (NIPT) for fetal blood group typing in Australia

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Maternal alloimmunisation against red blood cell antigens can cause haemolytic disease of the fetus and newborn (HDFN). Although most frequently caused by anti‐D, since the implementation of rhesus D (RhD)… Click to show full abstract

Maternal alloimmunisation against red blood cell antigens can cause haemolytic disease of the fetus and newborn (HDFN). Although most frequently caused by anti‐D, since the implementation of rhesus D (RhD) immunoglobulin prophylaxis, other alloantibodies have become more prevalent in HDFN. Recent advances in non‐invasive prenatal testing (NIPT) have allowed early prediction of HDFN risk in alloimmunised pregnancies and allow clinicians to focus health resources on those pregnancies that require intervention. This article aims to provide updates on the current status of NIPT in Australia as both a diagnostic and screening tool in pregnancy.

Keywords: invasive prenatal; testing nipt; non invasive; role non; prenatal testing; blood

Journal Title: Australian and New Zealand Journal of Obstetrics and Gynaecology
Year Published: 2021

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