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Hepatitis B surface antigen–positive donor to negative recipient lung transplantation

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A 63-year-old male presented with hypoxemic respiratory failure secondary to newly diagnosed idiopathic pulmonary fibrosis. Three weeks after his initial presentation, a compatible but increased risk donor with positive hepatitis… Click to show full abstract

A 63-year-old male presented with hypoxemic respiratory failure secondary to newly diagnosed idiopathic pulmonary fibrosis. Three weeks after his initial presentation, a compatible but increased risk donor with positive hepatitis B surface antigen (HBsAg) became available. A decision was made to accept the available lungs as the patient's clinical condition was deteriorating rapidly and the chances of survival were otherwise slim. Due to previous cardiac surgery resulting in mediastinal adhesions, a single right lung transplant was performed. The patient received induction immunosuppression with basiliximab and maintenance with tacrolimus, mycophenolate mofetil and low-dose prednisone.

Keywords: hepatitis surface; donor; surface antigen

Journal Title: American Journal of Transplantation
Year Published: 2020

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