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Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Human testicular germ cell tumours (TGCT) arise from germ cell neoplasia in situ (GCNIS) cells that originate from foetal germ cell precursors. Activin A is central to normal foetal testis… Click to show full abstract

Human testicular germ cell tumours (TGCT) arise from germ cell neoplasia in situ (GCNIS) cells that originate from foetal germ cell precursors. Activin A is central to normal foetal testis development, and its dysregulation may contribute to TGCT aetiology.

Keywords: expressed normal; target genes; genes differentially; germ cell; activin target; differentially expressed

Journal Title: Andrology
Year Published: 2019

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