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Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment

Oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm‐specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe… Click to show full abstract

Oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm‐specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have yet to be associated with general sperm viability.

Keywords: indicative optimal; zeta profiles; sperm; phospholipase zeta; profiles indicative; optimal sperm

Journal Title: Andrology
Year Published: 2020

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