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Expression of membrane fusion proteins in spermatozoa and total fertilisation failure during in vitro fertilisation

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Couples increasingly experience infertility and seek help from assisted reproductive techniques to become pregnant. However, 5%–15% of the couples that are selected for in vitro fertilisation (IVF) experience a total… Click to show full abstract

Couples increasingly experience infertility and seek help from assisted reproductive techniques to become pregnant. However, 5%–15% of the couples that are selected for in vitro fertilisation (IVF) experience a total fertilisation failure (TFF), where no zygotes develop despite oocytes and semen parameters appear to be normal. We hypothesise that TFF during IVF could be related to improper membrane fusion of gametes.

Keywords: total fertilisation; membrane fusion; fertilisation failure; vitro fertilisation; fertilisation

Journal Title: Andrology
Year Published: 2022

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