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Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether… Click to show full abstract
Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2‐receptor availability (Catechol‐O‐methyltransferase [COMT] Val158Met genotype and DRD2 C957T genotype) affect the development of cognitive deficits in PD.
Keywords:
polymorphisms dopamine;
cognitive decline;
parkinson disease
Journal Title: Acta Neurologica Scandinavica
Year Published: 2018
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Journal Title: Acta Neurologica Scandinavica
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!