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Nucleotide oligomerization domain polymorphism confers no risk to Guillain–Barré syndrome

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Nucleotide oligomerization domain (NOD) proteins are cytoplasmic receptors that play important roles in host innate immune responses to pathogens by recognizing self or non‐self‐molecules and have been implicated in many… Click to show full abstract

Nucleotide oligomerization domain (NOD) proteins are cytoplasmic receptors that play important roles in host innate immune responses to pathogens by recognizing self or non‐self‐molecules and have been implicated in many autoimmune diseases including Guillain–Barré syndrome (GBS). The current study investigated whether NOD polymorphisms (NOD1‐Glu266Lys, rs2075820, and NOD2‐ [Arg702Trp, rs2066844 and Gly908Arg, rs2066845]) contribute to ligand sensing and thus affect the susceptibility and/or severity of GBS.

Keywords: barr syndrome; oligomerization domain; nucleotide oligomerization; guillain barr

Journal Title: Acta Neurologica Scandinavica
Year Published: 2022

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