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Role of spatial dispersion of repolarization in reentry around a functional core versus reentry around a fixed anatomical core

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Successful initiation of spiral wave reentry in the neonatal rat ventricular myocyte (NRVM) monolayer implicitly assumes the presence of spatial dispersion of repolarization (DR), which is difficult to quantify. We… Click to show full abstract

Successful initiation of spiral wave reentry in the neonatal rat ventricular myocyte (NRVM) monolayer implicitly assumes the presence of spatial dispersion of repolarization (DR), which is difficult to quantify. We recently introduced a NRVM monolayer that utilizes anthopleurin‐A to impart a prolonged plateau to the NRVM action potential. This was associated with a significant degree of spatial DR that lends itself to accurate quantification.

Keywords: reentry; spatial dispersion; reentry around; dispersion repolarization; core

Journal Title: Annals of Noninvasive Electrocardiology
Year Published: 2019

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