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Sterol regulatory element binding protein‐1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer

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Women with polycystic ovary syndrome have a three‐fold higher risk of endometrial cancer. Insulin resistance and hyperlipidemia may be pertinent factors in the pathogenesis of both conditions. The aim of… Click to show full abstract

Women with polycystic ovary syndrome have a three‐fold higher risk of endometrial cancer. Insulin resistance and hyperlipidemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate endometrial sterol regulatory element binding protein‐1 gene expression in polycystic ovary syndrome and endometrial cancer endometrium, and to correlate endometrial sterol regulatory element binding protein‐1 gene expression with serum lipid profiles.

Keywords: polycystic ovary; regulatory element; endometrial cancer; ovary syndrome; sterol regulatory; element binding

Journal Title: Acta Obstetricia et Gynecologica Scandinavica
Year Published: 2017

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