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Maternal alloimmune antibodies against HPA and HLA class I antigens are associated with reduced birthweight among healthy neonates delivered by Chinese women

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It is well known that HPA‐1a antibodies lead to fetal and neonatal alloimmune thrombocytopenia (FNAIT), and an association with reduced birthweight in boys has been reported. Although it remains unclear… Click to show full abstract

It is well known that HPA‐1a antibodies lead to fetal and neonatal alloimmune thrombocytopenia (FNAIT), and an association with reduced birthweight in boys has been reported. Although it remains unclear whether HLA antibodies cause FNAIT, an association between HLA class I antibodies and reduced birthweight in FNAIT neonates has been observed. The aim of this study was to investigate the incidence of platelet antibodies among Chinese women and the impact of maternal alloimmune antibodies on birthweight among healthy neonates.

Keywords: hla class; birthweight among; maternal alloimmune; chinese women; alloimmune antibodies; reduced birthweight

Journal Title: Acta Obstetricia et Gynecologica Scandinavica
Year Published: 2022

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