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Hypothermic machine perfusion in uterus transplantation in a porcine model: A proof of concept and the first results in graft preservation

Graft optimization is a necessity in order to develop uterus transplantation from brain‐dead donors, as a complement to living donors, as these grafts are rare and the last organs retrieved… Click to show full abstract

Graft optimization is a necessity in order to develop uterus transplantation from brain‐dead donors, as a complement to living donors, as these grafts are rare and the last organs retrieved in multiple organ donation. The aim of this study was to assess the feasibility and interest of hypothermic machine perfusion (HMP) in uterus transplantation using a porcine model; secondary outcomes were the evaluation of the graft's tolerance to a prolonged cold ischaemia time and to find new biomarkers of uterus viability.

Keywords: uterus transplantation; machine perfusion; porcine model; transplantation; hypothermic machine

Journal Title: Acta Obstetricia et Gynecologica Scandinavica
Year Published: 2025

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