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Ascending infection is the leading cause of antepartum hemorrhage: A case–control study

Placental abruption is a significant obstetric complication characterized by the premature separation of the placenta from the uterine wall, affecting 2–3 per 100 pregnancies. This condition presents a dual diagnostic… Click to show full abstract

Placental abruption is a significant obstetric complication characterized by the premature separation of the placenta from the uterine wall, affecting 2–3 per 100 pregnancies. This condition presents a dual diagnostic challenge: obstetricians rely on clinical signs such as antepartum hemorrhage, abdominal pain, and ultrasound findings to suspect abruption, often leading to emergency cesarean delivery. Conversely, pathologists diagnose abruption through macroscopic and microscopic examination of placental tissue, identifying hematomas and signs of maternal vascular malperfusion. Notably, there is often a poor correlation between clinical diagnosis and pathological findings, with sensitivity reported as low as 30.2%. This study seeks to elucidate placental conditions associated with antepartum hemorrhage that may indicate abruption and emphasizes the importance of histopathological referral in understanding recurrence risks in subsequent pregnancies. By enhancing diagnostic accuracy, we aim to improve clinical outcomes for affected patients. Our objective is to evaluate placental conditions associated with antepartum hemorrhage and assess the correlation between clinical diagnoses and histopathological findings.

Keywords: abruption; antepartum hemorrhage; infection leading; ascending infection; hemorrhage; study

Journal Title: Acta Obstetricia et Gynecologica Scandinavica
Year Published: 2025

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