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Cutaneous exposure to hypoxia does not affect skin perfusion in humans

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Experiments have indicated that skin perfusion in mice is sensitive to reductions in environmental O2 availability. Specifically, a reduction in skin‐surface PO2 attenuates transcutaneous O2 diffusion, and hence epidermal O2… Click to show full abstract

Experiments have indicated that skin perfusion in mice is sensitive to reductions in environmental O2 availability. Specifically, a reduction in skin‐surface PO2 attenuates transcutaneous O2 diffusion, and hence epidermal O2 supply. In response, epidermal HIF‐1α expression increases and facilitates initial cutaneous vasoconstriction and subsequent nitric oxide‐dependent vasodilation. Here, we investigated whether the same mechanism exists in humans.

Keywords: hypoxia affect; perfusion; exposure hypoxia; skin perfusion; affect skin; cutaneous exposure

Journal Title: Acta Physiologica
Year Published: 2017

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