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Reductions in voltage‐gated sodium channel (Nav1.5) function/expression provide a slowed‐conduction substrate for cardiac arrhythmias. Nedd4‐2, which is activated by calcium, post‐translationally modulates Nav1.5. We aim to investigate whether elevated intracellular… Click to show full abstract
Reductions in voltage‐gated sodium channel (Nav1.5) function/expression provide a slowed‐conduction substrate for cardiac arrhythmias. Nedd4‐2, which is activated by calcium, post‐translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+]i) reduces Nav1.5 through Nedd4‐2 and its role in heart failure (HF).
Keywords:
calcium;
sodium channel;
heart failure;
channel nav1
Journal Title: Acta Physiologica
Year Published: 2017
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Journal Title: Acta Physiologica
Year Published: 2017
Link to full text (if available)
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recommendations!