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Collecting duct renin regulates potassium homeostasis in mice

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The kaliuretic action of the renin–angiotensin–aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The… Click to show full abstract

The kaliuretic action of the renin–angiotensin–aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the involvement of intrarenal RAAS in K+ homeostasis with emphasis on locally generated renin within the collecting duct (CD).

Keywords: collecting duct; homeostasis; raas; renin; duct renin

Journal Title: Acta Physiologica
Year Published: 2022

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