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The CaSR/TRPV4 coupling mediates pro‐inflammatory macrophage function

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Although calcium‐sensing receptor (CaSR) and transient receptor potential vanilloid 4 (TRPV4) channels are functionally expressed on macrophages, it is unclear if they work coordinately to mediate macrophage function. The present… Click to show full abstract

Although calcium‐sensing receptor (CaSR) and transient receptor potential vanilloid 4 (TRPV4) channels are functionally expressed on macrophages, it is unclear if they work coordinately to mediate macrophage function. The present study investigates whether CaSR couples to TRPV4 channels and mediates macrophage polarization via Ca2+ signaling.

Keywords: casr; casr trpv4; macrophage function

Journal Title: Acta Physiologica
Year Published: 2023

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