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Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide‐sensitive NaCl cotransporter (NCC) in the kidney has been shown to… Click to show full abstract
Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide‐sensitive NaCl cotransporter (NCC) in the kidney has been shown to be responsible for the development of hyperkalemic hypertension. In this study, we tested whether CsA induces the activation of NCC by stimulating the basolateral Kir4.1/Kir5.1 channel in the distal convoluted tubule (DCT).
Keywords:
hypertension;
hyperkalemic hypertension;
nacl cotransporter;
induced stimulation;
kir4 kir5
Journal Title: Acta Physiologica
Year Published: 2023
Link to full text (if available)
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Journal Title: Acta Physiologica
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!