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A potent and selective activator of large‐conductance Ca2+‐activated K+ channels induces preservation of mitochondrial function after hypoxia and reoxygenation by handling of calcium and transmembrane potential

Ischaemic heart disease remains a significant cause of mortality globally. A pharmacological agent that protects cardiac mitochondria against oxygen deprivation injuries is welcome in therapy against acute myocardial infarction. Here,… Click to show full abstract

Ischaemic heart disease remains a significant cause of mortality globally. A pharmacological agent that protects cardiac mitochondria against oxygen deprivation injuries is welcome in therapy against acute myocardial infarction. Here, we evaluate the effect of large‐conductance Ca2+‐activated K+ channels (BKCa) activator, Compound Z, in isolated mitochondria under hypoxia and reoxygenation.

Keywords: hypoxia reoxygenation; large conductance; ca2 activated; activated channels; conductance ca2

Journal Title: Acta Physiologica
Year Published: 2024

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