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Chronic High‐Fat Diet Consumption Followed by Lipopolysaccharide Challenge Induces Persistent and Long‐Lasting Microglial Priming, Mediates Synaptic Elimination via Complement C1q, and Leads to Behavioral Abnormalities in Male Wistar Rats

Microglia exhibit innate immune memory, altering their responses to subsequent challenges. Consumption of high‐fat diet (HFD) triggers innate immune responses, but the characteristics of HFD‐induced microglial priming remain unclear. We… Click to show full abstract

Microglia exhibit innate immune memory, altering their responses to subsequent challenges. Consumption of high‐fat diet (HFD) triggers innate immune responses, but the characteristics of HFD‐induced microglial priming remain unclear. We aim to investigate how HFD‐induced microglial priming, followed by a lipopolysaccharide (LPS) challenge, affects brain functions.

Keywords: microglial priming; fat diet; followed lipopolysaccharide; priming; high fat

Journal Title: Acta Physiologica
Year Published: 2025

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