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Previous studies demonstrated direct correlation between CYP2C19 genotype and BMS‐823778 clearance in healthy volunteers. The objective of the present study was to develop a physiologically‐based pharmacokinetic (PBPK) model for BMS‐823778… Click to show full abstract
Previous studies demonstrated direct correlation between CYP2C19 genotype and BMS‐823778 clearance in healthy volunteers. The objective of the present study was to develop a physiologically‐based pharmacokinetic (PBPK) model for BMS‐823778 and use the model to predict PK and drug–drug interaction (DDI) in virtual populations with multiple polymorphic genes.
Keywords:
based pharmacokinetic;
pharmacokinetic modelling;
bms 823778;
physiologically based;
modelling cyp2c19
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2018
Link to full text (if available)
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2018
Link to full text (if available)
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recommendations!