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CYP2E1 activity and children with obesity: possible confounding factors

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Lots of factors can influence CYP2E1 activities, e.g. thyroid status, different types of anaemia (fanconi anaemia and sideroblastic anaemia), etc. Alcohol is a known inducer of CYP2E1, therefore a justifiable… Click to show full abstract

Lots of factors can influence CYP2E1 activities, e.g. thyroid status, different types of anaemia (fanconi anaemia and sideroblastic anaemia), etc. Alcohol is a known inducer of CYP2E1, therefore a justifiable duration of abstinence is required before the subjects are enrolled into a study for normalization of CYP2E1 activity. In this letter we address these confounding factors and their role in CYP2E1 activity.

Keywords: activity children; children obesity; obesity possible; confounding factors; cyp2e1 activity; activity

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019

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