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Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India

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Pharmacokinetic studies in the past have shown inadequate antituberculosis drug levels in children with the currently available dosing regimens. This study attempted to investigate the pharmacokinetics of isoniazid and rifampicin,… Click to show full abstract

Pharmacokinetic studies in the past have shown inadequate antituberculosis drug levels in children with the currently available dosing regimens. This study attempted to investigate the pharmacokinetics of isoniazid and rifampicin, when used in children, and to optimize their dosing regimens.

Keywords: regimens isoniazid; dosing regimens; children tuberculosis; rifampicin children; optimization dosing; isoniazid rifampicin

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019

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