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Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The… Click to show full abstract
Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was to characterize the complex pharmacokinetics of agomelatine and its metabolites in healthy subjects.
Keywords:
pharmacokinetic model;
population pharmacokinetic;
model agomelatine;
semiphysiological population;
agomelatine;
agomelatine metabolites
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019
Link to full text (if available)
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!