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Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure‐lowering

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Dietary inorganic nitrate (NO3−) lowers peripheral blood pressure (BP) in healthy volunteers, but lacks such effect in individuals with, or at risk of, type 2 diabetes mellitus (T2DM). Whilst this… Click to show full abstract

Dietary inorganic nitrate (NO3−) lowers peripheral blood pressure (BP) in healthy volunteers, but lacks such effect in individuals with, or at risk of, type 2 diabetes mellitus (T2DM). Whilst this is commonly assumed to be a consequence of chronic hyperglycaemia/hyperinsulinaemia, we hypothesized that acute physiological elevations in plasma [glucose]/[insulin] blunt the haemodynamic responses to NO3−, a pertinent question for carbohydrate‐rich Western diets.

Keywords: acute interaction; inorganic nitrate; blood pressure

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019

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