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Tocilizumab has a direct effect on inflammatory markers. Therefore, composite measures for disease activity assessment in rheumatoid arthritis (RA) using these inflammatory markers may not be suitable for tocilizumab treatment.… Click to show full abstract
Tocilizumab has a direct effect on inflammatory markers. Therefore, composite measures for disease activity assessment in rheumatoid arthritis (RA) using these inflammatory markers may not be suitable for tocilizumab treatment. We used a modelling approach to describe the tocilizumab exposure‐response relationship and to investigate the different dynamics of the individual components of the routinely used continuous composite measures.
Keywords:
exposure response;
composite measures;
continuous composite;
individual components;
rheumatoid arthritis;
arthritis using
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019
Link to full text (if available)
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019
Link to full text (if available)
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recommendations!