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Steady‐state population pharmacokinetics of terizidone and its metabolite cycloserine in patients with drug‐resistant tuberculosis

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Despite terizidone being part of the second‐line recommended drugs for treatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokinetics is scarce. The aim of this study was to describe the… Click to show full abstract

Despite terizidone being part of the second‐line recommended drugs for treatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokinetics is scarce. The aim of this study was to describe the steady‐state population pharmacokinetics (PPK) of terizidone and its primary metabolite cycloserine in patients with DR‐TB and determine the effect of patient characteristics.

Keywords: metabolite cycloserine; state population; drug resistant; population pharmacokinetics; steady state; resistant tuberculosis

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019

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