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Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis

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To propose new exposure targets for Bayesian dose optimisation suited for high‐dose rifampicin and to apply them using measured plasma concentrations coupled with a Bayesian forecasting algorithm allowing predictions of… Click to show full abstract

To propose new exposure targets for Bayesian dose optimisation suited for high‐dose rifampicin and to apply them using measured plasma concentrations coupled with a Bayesian forecasting algorithm allowing predictions of future doses, considering rifampicin's auto‐induction, saturable pharmacokinetics and high interoccasion variability.

Keywords: high dose; dose rifampicin; algorithm; individualised dosing

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2019

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