LAUSR

Pheochromocytoma crisis is an exceptional consequence of the release of storage vesicles of the adrenal medulla. It is complicated by fulminant adrenergic myocarditis. It offers a unique opportunity to detect inotropic negative factors from neuroendocrine origin. Our objectives were: 1) to describe a pheochromocytoma crisis 2) to investigate in vivo myocardial depressant activities for the N-terminal 1-76 Chromogranin A-derived peptide, Vasostatin-I. A patient with a pheochromocytoma crisis was treated including extracorporeal membrane oxygenation until mass resection. Plasma concentrations of Vasostatin-I were time-dependently assessed with a specific immunoassay; correlations with invasive cardiovascular parameters were investigated. Increased Vasostatin-I concentrations were observed over 7 days until tumor resection. Vasostatin-I concentrations correlated positively with Chromogranin A levels, negatively with cardiac output and left ventricular stroke work index, but not with heart rate. This case illustrates pharmacokinetics of Vasostatin-I in a pheochromocytoma crisis. It highlights myocardial depressant activity for this peptide at high concentrations.