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Changes in serotonergic sensory modulation associated with overexpression of 5‐HT3 receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage.… Click to show full abstract
Changes in serotonergic sensory modulation associated with overexpression of 5‐HT3 receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5‐HT3 receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, but have limited effectiveness, due potentially to limited CNS access. However, there is currently limited information on CNS disposition of systemically‐administered 5‐HT3 receptor antagonists. This study evaluated the cerebrospinal fluid (CSF) disposition of ondansetron, as a surrogate of CNS penetration.
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020
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