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Model‐informed drug repurposing: Viral kinetic modelling to prioritize rational drug combinations for COVID‐19

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We hypothesized that viral kinetic modelling could be helpful to prioritize rational drug combinations for COVID‐19. The aim of this research was to use a viral cell cycle model of… Click to show full abstract

We hypothesized that viral kinetic modelling could be helpful to prioritize rational drug combinations for COVID‐19. The aim of this research was to use a viral cell cycle model of SARS‐CoV‐2 to explore the potential impact drugs, or combinations of drugs, that act at different stages in the viral life cycle might have on various metrics of infection outcome relevant in the early stages of COVID‐19 disease.

Keywords: prioritize rational; drug; viral kinetic; rational drug; kinetic modelling; drug combinations

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020

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